What is glutathione?
Glutathione, a sulfur-containing compound, is the master detoxifier and main antioxidant in the body. A combination of three simple building blocks of proteins or amino acids—cysteine, glycine, and glutamine—glutathione is part of a larger family of enzymes comprising the powerful detoxification group called glutathione-S-transferase (GST).
Low levels of glutathione are associated with immune deficiency, progression of chronic diseases, and aging.
What are the potential health benefits of glutathione?
- Supports healthy immune function
- Helps control inflammation
- Detoxifies unhealthy substances
- Protects cells
- Aids functional energy metabolism
- Assists amino acid transport1
Along with antioxidant defense of the cell, glutathione plays a central role in drug detoxification and cell communication impacting the regulation of gene expression, cell death, and cell growth2.
What are additional potential health benefits of glutathione for some cancer patients?
Studies also suggest that intravenous glutathione reduces and protects against toxicity, cancer side effects, improves or maintains quality of life, and enhances therapeutic effects in some cancer patients treated with certain chemotherapy agents3-7.
Glutathione may also help treat cancer cachexia. The progression of cancer cachexia is associated with the depletion of intracellular glutathione (GSH) and increases in markers of oxidative stress due to high levels of toxicity in the body8.
Some research indicates contraindications between glutathione and some chemotherapy agents related to antioxidants and their interference.
What causes decreases in glutathione?
A poor diet, pollution, toxins, medications, alcohol, smoking, lack of exercise, stress, trauma, aging, infections, radiation, cancer cells, conventional cancer treatments, and other factors produce oxidative stress generating free radicals that may decrease glutathione levels. Free radicals are unstable molecules that play a role in illness. Oxidation involves the loss of an electron from an atom or molecule. Since atoms and molecules want to have a full set of electrons, free radicals that form during oxidative stress search for and combine with other molecules to acquire electrons. In this process, free radicals can damage DNA. Since pieces of DNA are genes telling cells how to work in the body, when to grow, and divide, free radicals can initiate cancer development and growth.
As a master detoxifier and antioxidant in the body, glutathione is responsible for removing excess free radicals. However, if the amount of free radicals is higher than available glutathione, the body’s total level of glutathione will decrease.
What are some strategies to increase glutathione?
Glutathione can be taken nebulized, orally or intravenously. Overall, intravenous glutathione delivers the highest levels of the substance with increased absorption.
What are other sources of glutathione?
Specific foods and supplements provide glutathione.
- Sulfur-rich foods—garlic, onions, and cruciferous vegetables
- Bioactive whey protein
- Alpha lipoic acid
- Methylation nutrients folate and vitamins B6 and B12
- Milk thistle
- Antioxidants such as Vitamin C and E
What is the role of glutathione genetic variations in health conditions such as cancer?
Genes are involved in glutathione metabolism to produce enzymes that allow the body to create and recycle glutathione. These genes have many names such as GSTM1 and GSTP1. Studies suggest that different glutathione-S-transferase (GST) gene abnormalities may correlate with cancer diagnosis, response to cancer therapies, and even survival9-11. Some health care providers test patients to measure these genes for information about strengths and weaknesses in glutathione metabolism. This customized information about each person provides details about bodily functions and helps direct treatments.
For More Information
- The Definitive Guide to Cancer, 3rd Edition: An Integrative Approach to Prevention, Treatment, and Healing by Lise Alschuler, ND and Karolyn A. Gazella
- Textbook of Functional Medicine